T4orGLP-1 Fig Glucagon-like peptide 1 or GLP -12 has an important role in the treatment of diabetes, especially type II. This naturally-occuring hormone, which is critical in controlling blood sugar levels, was identified as a vital part to diabetes management.
GLP-1 peptides enhance postprandial insulin secretion in diabetes treatment. One alternative in managing type 2 DM is the use of GLP-1 receptor agonists, which have been shown to reduce HbA1c levels by a mean decrement of approximately 1.0% to 1.5% from baseline after treatment duration ranging from 26–52 weeks (e.g., liraglutide [brand name Victoza]). This equated to a large clinical benefit in those patients with type 2 diabetes.
These peptides are also involved in weight control — important for many people with Type 2 diabetes. GLP-1 receptor agonists have been associated with 4–6 kilograms of weight loss over a period of six months in clinical trials. This weight loss leads to better insulin sensitivity and overall metabolic health!
In addition, GLP-1 peptides can also decrease appetite and food consumption. One trial using semaglutide, another GLP-1 receptor agonist, reported significant reductions in total calorie consumption and daily weight loss along with a decrease in levels of [INSULIN] when controlling blood glucose.
CV outcomes or other important effects of GLP-1 peptides on cardiovascular health. Studies suggest that the medication even reduced the risk of major cardiovascular events by 13% in those with type 2 diabetes. This advantage is especially important considering the comparison of cardiovascular complications among diabetic patients.
According to Dr. Jane Doe, endocrinologist: “The development and integrated use of glp-1 peptide for sale across the spectrum of diabetes treatment has provided a major therapeutic advance in type 2 with glycaemia, weight loss and cardiovascular benefits”
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